Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377386 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A series of new bisphenol derivatives bearing allylic moieties were synthesized as potential analogs of honokiol and/or magnolol. Certain compounds exhibited specific anti-proliferation activity against SVR cells and moderate anti-HIV-1 activity in primary human lymphocytes. Compound 5h was the most potent compound and its anti-tumor activity was evaluated in vivo.
Graphical abstractThe synthesis of a series of new bisphenol derivatives bearing allylic moieties as potential analogs of honokiol and/or magnolol is reported. Certain compounds exhibited specific anti-proliferation activity and moderate anti-HIV-1 activity in vitro.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Franck Amblard, Baskaran Govindarajan, Benjamin Lefkove, Kimberly L. Rapp, Mervi Detorio, Jack L. Arbiser, Raymond F. Schinazi,