Article ID Journal Published Year Pages File Type
1377386 Bioorganic & Medicinal Chemistry Letters 2007 4 Pages PDF
Abstract

A series of new bisphenol derivatives bearing allylic moieties were synthesized as potential analogs of honokiol and/or magnolol. Certain compounds exhibited specific anti-proliferation activity against SVR cells and moderate anti-HIV-1 activity in primary human lymphocytes. Compound 5h was the most potent compound and its anti-tumor activity was evaluated in vivo.

Graphical abstractThe synthesis of a series of new bisphenol derivatives bearing allylic moieties as potential analogs of honokiol and/or magnolol is reported. Certain compounds exhibited specific anti-proliferation activity and moderate anti-HIV-1 activity in vitro.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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