| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377393 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
An unusual new cyclic peptide with a pyrrolidine-2,5-dione unit, gypsophin (1), was isolated from Gypsophila oldhamiana. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was determined by application of the Marfey’s method and the single-crystal X-ray diffraction. Compound 1 exhibited inhibitory activity against α-glucosidase with IC50 of 305 μM.
Graphical abstractThe elucidation and the α-glucosidase inhibitory activity of a new cyclic peptide are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jian-Guang Luo, Xiao-Bing Wang, Li Ma, Ling-Yi Kong,