| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377394 | Bioorganic & Medicinal Chemistry Letters | 2007 | 7 Pages |
Abstract
A novel series of benzimidazoles was identified and optimized, leading to the discovery of potent and selective antagonists of the human melanocortin-4 receptor. In addition, compound 5i was shown to cross the blood–brain barrier after intravenous dosing in rats.
Graphical abstractA novel series of benzimidazoles was identified and optimized, leading to the discovery of potent and selective antagonists of the human melanocortin-4 receptor. In addition, compound 5i was shown to cross the blood–brain barrier after intravenous dosing in rats.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lydie Poitout, Valérie Brault, Carole Sackur, Sonia Bernetière, José Camara, Pascale Plas, Pierre Roubert,