Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377402 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Some 6-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives (4a–f and 5a–d) have been synthesized by cyclisation of 4-amino-5-[1-(6-methoxy-2-naphthyl)ethyl]-3-mercapto-(4H)-1,2,4-triazole (3) with various substituted aromatic acids and aryl/alkyl isothiocyanates, through a single step reaction. The target compounds were pharmacologically evaluated for their anti-inflammatory and analgesic potentials by known experimental models. Several of these showed significant activity. Very low ulcerogenic index was observed for potent compounds.
Graphical abstractSome 6-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives (4a–f and 5a–d) have been synthesized by cyclisation of 4-amino-5-[1-(6-methoxy-2-naphthyl)ethyl]-3-mercapto-(4H)-1,2,4- triazole (3) with various substituted aromatic acids and aryl/alkyl isothiocyanates, through a single step reaction. The target compounds were pharmacologically evaluated for their anti-inflammatory and analgesic potentials by known experimental models.Figure optionsDownload full-size imageDownload as PowerPoint slide