Synthesis and antibacterial activity of novel fluoroquinolones containing substituted piperidines

The design and synthesis of new fluoroquinolone antibacterial agents having substituted piperidine rings at the C-7 position are described. Most of the new compounds demonstrated high in vitro antibacterial activity. Several of them exhibited significant activities against Gram-positive organisms, which were more potent than those of gemifloxacin, Linezolid, and vancomycin.

Graphical abstractThe design, synthesis, and antibacterial activity of new fluoroquinolones possessing substituted piperidine rings at the C-7 position are described.Figure optionsDownload full-size imageDownload as PowerPoint slide