| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377416 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Substituted 3-aminopiperidines 3 were evaluated as DPP-4 inhibitors. The inhibitors showed good DPP-4 potency with superb selectivity over other peptidases (QPP, DPP8, and DPP9). Selected DPP-4 inhibitors were further evaluated for their hERG potassium channel, calcium channel, Cyp2D6, and pharmacokinetic profiles.
Graphical abstractSubstituted 3-aminopiperidines 3 were evaluated as DPP-4 inhibitors. The inhibitors showed good DPP-4 potency with superb selectivity over other peptidases (QPP, DPP8, and DPP9). Selected DPP-4 inhibitors were further evaluated for their hERG potassium channel, L-type calcium channel, Cyp2D6, and pharmacokinetic profiles.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Jason M. Cox, Bart Harper, Anthony Mastracchio, Barbara Leiting, Ranabir Sinha Roy, Reshma A. Patel, Joseph K. Wu, Kathryn A. Lyons, Huaibing He, Shiyao Xu, Bing Zhu, Nancy A. Thornberry, Ann E. Weber, Scott D. Edmondson,