Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377422 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
The design and synthesis of novel series of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid (pyrimidone) derivatives that are high affinity ligands for peroxisome proliferators activated receptor γ have been reported as a potential substitute of 2,4-thiazolidinedione head group. The FlexX docking and radioligand binding affinity of some promising compounds of this series is comparable to that of thiazolidinedione based antidiabetic drugs currently in clinical use.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rakesh Kumar, Amit Mittal, Uma Ramachandran,