| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377425 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of benzodiazepines and benzazepinones were synthesized and evaluated as potential sodium channel blockers in a functional, membrane potential-based assay. One member of the benzazepinone series, compound 47, displayed potent, state-dependent block of hNav1.7, and was orally efficacious in a rat model of neuropathic pain.
Graphical abstractA series of benzodiazepines and benzazepinones were synthesized and evaluated as potential sodium channel blockers in a functional, membrane potential-based assay. One member of the benzazepinone series, compound 47, displayed potent, state-dependent block of hNav1.7, and was orally efficacious in a rat model of neuropathic pain.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Organic Chemistry
Authors
Scott B. Hoyt, Clare London, David Gorin, Matthew J. Wyvratt, Michael H. Fisher, Catherine Abbadie, John P. Felix, Maria L. Garcia, Xiaohua Li, Kathryn A. Lyons, Erin McGowan, D. Euan MacIntyre, William J. Martin, Birgit T. Priest, Amy Ritter,