| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377427 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
The design and synthesis of α-helix peptidomimetics using inverse electron demand Diels–Alder reactions is described. The potency of the resulting pyridazine-based library to disrupt the Bak/Bcl-XL interaction was tested using an in vitro fluorescence polarization assay.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Shannon M. Biros, Lionel Moisan, Enrique Mann, Alexandre Carella, Dayong Zhai, John C. Reed, Julius Rebek Jr.,