| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377432 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
The discovery of a series of potent, carboline-based MK2 inhibitors is described. These compounds inhibit MK2 with IC50s as low as 10 nM, as measured in a DELFIA assay. An X-ray crystal structure reveals that they bind in a region near the p-loop and the hinge region of MK2a.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jiang-Ping Wu, Ji Wang, Asitha Abeywardane, Denise Andersen, Michel Emmanuel, Elda Gautschi, Daniel R. Goldberg, Mohammed A. Kashem, Susan Lukas, Wang Mao, Leslie Martin, Tina Morwick, Neil Moss, Christopher Pargellis, Usha R. Patel, Lori Patnaude,