Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists

A combination of benzoxazole, phenoxyalkyl side chain, and phenoxybutyric acids was identified as a highly potent and selective human peroxisome proliferator-activated receptor α (PPARα) agonist. The synthesis, structure–activity relationship (SAR) studies, and in vivo activities of the representative compounds are described.

Graphical abstractA combination of benzoxazole, phenoxyalkyl side chain and phenoxybutyric acids was identified as highly potent and selective h-PPARα agonists. The synthesis, SAR studies and in vivo activities of the representative compounds are described.Figure optionsDownload full-size imageDownload as PowerPoint slide