Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377440 | Bioorganic & Medicinal Chemistry Letters | 2007 | 7 Pages |
Abstract
Starting from a biased needle screening hit 3a, we report herein the design and synthesis of a series of novel 2,3-dihydroisoindol-1-ones structurally related to cyclothialidine 2 with DNA gyrase inhibitory activity. In this series, some compounds exhibited promising antibacterial activity against Gram-positive bacterial strains.
Graphical abstractStarting from 2-(anilinomethyl)-phenols 3 we report herein the design and synthesis of a series of novel 2,3-dihydroisoindol-1-ones structurally related to cyclothialidine 2 with DNA gyrase inhibitory activity. In this series, some compounds exhibited promising antibacterial activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thomas Lübbers, Peter Angehrn, Hans Gmünder, Silvia Herzig,