Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377448 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of novel carboxylic acid-based α-sulfone MMP inhibitors have been synthesized and the in vitro enzyme SAR is discussed. A potential binding mode in the active site of the MMP-9 homology model was highlighted. These compounds are potent MMP-9 inhibitors and are selective over MMP-1.
Graphical abstractA series of novel carboxylic acid-based α-sulfone MMP inhibitors have been synthesized and the in vitro enzyme SAR and in vivo PK evaluation are discussed. These compounds are potent MMP-9 inhibitors and are selective over MMP-1.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yue-Mei Zhang, Xiaodong Fan, Bangping Xiang, Devraj Chakravarty, Robert Scannevin, Sharon Burke, Prabha Karnachi, Kenneth Rhodes, Paul Jackson,