Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377449 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
[11C]5 and [11C]6 display high affinity for the NET in vitro (Ki = 0.94 and 0.68 nM, respectively) and significant selectivity over the dopamine (DAT) and serotonin transporters (SERT). Because of their high affinity and favorable transporter selectivities we speculated that these ligands might serve as useful PET agents for imaging NET in vivo. Contrary to our expectations, both of these ligands provided brain images that were more typical of those shown by agents binding to the DAT.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John L. Musachio, Jinsoo Hong, Masanori Ichise, Nicholas Seneca, Amira K. Brown, Jeih-San Liow, Christer Halldin, Robert B. Innis, Victor W. Pike, Rong He, Jia Zhou, Alan P. Kozikowski,