Carboxy derivatized glucosamine is a potent inhibitor of matrix metalloproteinase-9 in HT1080 cells

Experimental evidences have confirmed that matrix metalloproteinases (MMPs) play a fundamental role in a wide variety of pathologic conditions and recent advances in medicinal chemistry approach to the design of MMP inhibitors with desired structural and functional properties. Among MMPs, MMP-9 has demonstrated to play a major role in the establishment of metastases and it is substantially increased in the majority of malignant tumors. Inhibition of MMP-9 is thought to have a therapeutic benefit to cancer. Results of this study present a novel synthetic MMP-9 inhibitor that downregulates MMP-9 expression level in HT1080, human fibrosarcoma cells.

Graphical abstractCarboxylated glucosamine (CGlc) synthesized through substitution of –OOC–CH2CH2–CO– group to glucosamine hydrochloride (Glc) exhibited a potent matrix metalloproteinase-9 (MMP-9) expression inhibition in HT1080, human fibrosarcoma cells.Figure optionsDownload full-size imageDownload as PowerPoint slide