| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377453 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
CHK-1 is one of the key enzymes regulating checkpoints in cellular growth cycles. Novel 4-(amino-alkylamino)-3-benzimidazole-quinolinones were prepared and assayed for their ability to inhibit CHK-1. These compounds are potent cell permeable CHK-1 inhibitors and showed synergistic effect with a DNA-damaging agent, camptothecin.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhi-Jie Ni, Paul Barsanti, Nathan Brammeier, Anthony Diebes, Daniel J. Poon, Simon Ng, Sabina Pecchi, Keith Pfister, Paul A. Renhowe, Savithri Ramurthy, Allan S. Wagman, Dirksen E. Bussiere, Vincent Le, Yasheen Zhou, Johanna M. Jansen, Sylvia Ma,