Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377466 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Analogues of the tetrahydroisoquinoline family of antitumor antibiotics, 3-epi-jorumycin (3) and 3-epi-renieramycin G (4), in addition to their respective parent natural products (â)-jorumycin (1) and (â)-renieramycin G (2) were evaluated against both human colon (HCT-116) and human lung (A549) cancer cell lines. (â)-Jorumycin (1) displayed potent growth inhibition with GI50 values in the low nanomolar range (1.9-24.3 nM), while compounds 2-4 were found to be substantially less cytotoxic (GI50 0.6-14.0 μM).
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Authors
Jonathan W. Lane, Alberto Estevez, Kyle Mortara, Ondine Callan, Jeffrey R. Spencer, Robert M. Williams,