| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377476 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Synthetic hybridization of two privileged drug scaffolds, pyrazolone on the one hand and pyrimidine nucleoside on the other, resulted in the generation of two novel 5-substituted pyrimidine nucleosides with potent in vitro antiviral activity against two representative orthopoxviruses, vaccinia virus and cowpox virus.
Graphical abstract5-Formyl-2′-deoxyuridine was condensed with 1-phenyl-3-methyl-2-pyrazolin-5-one to give a novel pyrimidinylidene–pyrazolone nucleoside (9) with potent in vitro anti-orthopoxvirus properties.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xuesen Fan, Xinying Zhang, Longhu Zhou, Kathy A. Keith, Earl R. Kern, Paul F. Torrence,