| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377484 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The preparation of three different 2-alkoxy-8-hydroxyadenylpeptide conjugates has been accomplished by solid-phase synthesis combined with ‘on-resin’ Cu(I) catalyzed Huisgen cycloaddition. The immunogenicity of the compounds has been evaluated in IL-12 production and antigen presentation assays.
Graphical abstractThe design, synthesis and immunogenic properties of 2-alkoxy-8-hydroxyadenylpeptides are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jimmy J. Weterings, Selina Khan, Gerbrand J. van der Heden, Jan W. Drijfhout, Cornelis J.M. Melief, Herman S. Overkleeft, Sjoerd H. van der Burg, Ferry Ossendorp, Gijsbert A. van der Marel, Dmitri V. Filippov,