| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377486 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of substituted pyrrolidine-2,4-dicarboxylic acid amides were synthesized as potential antidiabetic agents, and many of them showed good in vitro DPP-IV inhibition (IC50 = 2–250 nM) with selectivity over DPP-II, DPP8, and FAP enzymes. Selected compounds 8c and 11a showed in vivo plasma DPP-IV inhibition after oral administration in Wistar rats.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ting-Yueh Tsai, Mohane Selvaraj Coumar, Tsu Hsu, Hsing-Pang Hsieh, Chia-Hui Chien, Chiung-Tong Chen, Chung-Nien Chang, Yu-Kang Lo, Ssu-Hui Wu, Chung-Yu Huang, Yu-Wen Huang, Min-Hsien Wang, Hsin-Yi Wu, Hong-Jen Lee, Xin Chen, Yu-Sheng Chao,