| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377491 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
We report the design, semisynthesis, and biological activity of a series of fredericamycin (1) derivatives. Within this series compound 1e combines low nanomolar cytotoxic potency in vitro, increased tumor cell line selectivity, and in vivo activity in a human xenograft model.
Graphical abstractStarting from natural Fredericamycin A, a series of semisynthetic derivatives was prepared exhibiting increased potency and selectivity in vitro in a human tumor cell line panel.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ulrich Abel, Werner Simon, Peter Eckard, Friedrich G. Hansske,