| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377501 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 μM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated.
Graphical abstractBoesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 μM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated. Lineweaver–Burk plot of inhibitor compound 6, 4-hydroxypanduratin A.Figure optionsDownload full-size imageDownload as PowerPoint slide
