| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377515 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Oxazolidinone analogs bearing substituted piperidine or azetidine C-rings are described. Analogs with a methyl group at the 3-position of the azetidine ring or the 4-position of the piperidine ring exhibited reduced mitochondrial protein synthesis inhibition while retaining good antibacterial potency.
Graphical abstractOxazolidinone analogs bearing substituted piperidine or azetidine C-rings are described. Analogs with a methyl group at the 3-position of the azetidine ring or the 4-position of the piperidine ring exhibited reduced mitochondrial protein synthesis inhibition while retaining good antibacterial potency.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Adam R. Renslo, Andy Atuegbu, Prudencio Herradura, Priyadarshini Jaishankar, Mingzhe Ji, Karen L. Leach, Michael D. Huband, Michael R. Dermyer, Luping Wu, J.V.N. Vara Prasad, Mikhail F. Gordeev,