Article ID Journal Published Year Pages File Type
1377526 Bioorganic & Medicinal Chemistry Letters 2007 5 Pages PDF
Abstract

We have recently reported the discovery of a novel class of glucocorticoid receptor (GR) antagonists, exemplified by 3, containing a 1,2-dihydroquinoline molecular scaffold. Further SAR studies of these antagonists uncovered chemical modifications conveying agonist functional activity to this series. These agonists exhibit good GR binding affinity and are selective against other nuclear hormone receptors.

Graphical abstractThe SAR study of novel class of glucocorticoid receptor agonist is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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