Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377530 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines represent a novel class of compounds with activity against pestiviruses and the hepatitis C virus (HCV). Several series of analogues with modifications of the substituents in positions 2 and 5 were prepared. These efforts resulted in the discovery of several compounds with potent antiviral activity of which 2-(2,3-difluorophenyl)-5-[4-(trifluoromethyl)benzyl]-5H-imidazo[4,5-c]pyridine (46) was most potent against HCV (EC50 of 0.10 μM and a selectivity index of 1080).
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gerhard Puerstinger, Jan Paeshuyse, Susanne Heinrich, Joachim Mohr, Nicole Schraffl, Erik De Clercq, Johan Neyts,