| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377539 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Substituted quinolyl oxazoles were discovered as a novel and highly potent series of phosphodiesterase 4 (PDE4) inhibitors. Structure–activity relationship studies revealed that the oxazole core, with 4-carboxamide and 5-aminomethyl groups, is a novel PDE4 inhibitory pharmacophore. Selectivity profiles and in vivo biological activity are also reported.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rongze Kuang, Ho-Jane Shue, David J. Blythin, Neng-Yang Shih, Danlin Gu, Xiao Chen, John Schwerdt, Ling Lin, Pauline C. Ting, Xiaohong Zhu, Robert Aslanian, John J. Piwinski, Li Xiao, Daniel Prelusky, Ping Wu, Ji Zhang, Xiang Zhang, Chander S. Celly,