| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377542 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
A series of pyrrolidine derivatives were synthesized and characterized as potent agonists of the human melanocortin-4 receptor. For example, 28c had a Ki of 13 nM in binding affinity and EC50 of 6.9 nM in agonist potency with an intrinsic activity of 100% of the endogenous ligand α-MSH.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Joe A. Tran, Caroline W. Chen, Wanlong Jiang, Fabio C. Tucci, Beth A. Fleck, Dragan Marinkovic, Melissa Arellano, Chen Chen,