| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377545 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Nobiletin, a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-carcinogenic activities. The metabolite identification of nobiletin in mouse urine has concluded that it undergoes mono-demethylation (3′- and 4′-demethylnobiletin) and di-demethylation (3′,4′-didemethylnobiletin) metabolic pathway. Biological screening of nobiletin and its metabolites has revealed that the metabolites possess more potent anti-inflammatory activity than their parent compound. Therefore, this letter reports the identification of nobiletin metabolites and their anti-inflammatory activity against LPS-induced NO production and iNOS, COX-2 protein expression in RAW264.7 macrophage.
Graphical abstractThe identification and anti-inflammatory activity of nobiletin metabolites in mouse urine is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
