PASS-predicted design, synthesis and biological evaluation of cyclic nitrones as nootropics

Out of 400 virtually designed imidazoline N-oxides, five cyclic nitrones were selected on the basis of PASS prediction as potent nootropics and were evaluated for their biological activities in albino mice. The selected N-alkyl and aryl-substituted nitrones were found to be excellent nootropics. A series of lead compounds acting as cognition enhancers have been provided, which can be further exploited in search of such New Chemical Entities (NCEs).

Graphical abstractSome N-alkyl and N-aryl-substituted cyclic nitrones typified as 3 were designed with the help of PASS prediction, synthesized and evaluated pharmacologically as excellent nootropics/cognition enhancers.Figure optionsDownload full-size imageDownload as PowerPoint slide