| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377575 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
AMP-activated protein kinase (AMPK) is well established as a sensor and regulator of intracellular and whole-body energy metabolism. A high-throughput screen was performed in order to identify chemotypes that are bound by AMPK. A novel thienopyridone compound (1) was identified and subsequently optimized. The structure–activity relationships that emerged from this effort are described.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gang Zhao, Rajesh R. Iyengar, Andrew S. Judd, Barbara Cool, William Chiou, Lemma Kifle, Ernst Frevert, Hing Sham, Philip R. Kym,