| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377578 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A novel series of 4-aryl-5-cyano-2-aminopyrimidines were synthesized and found to have potent VEGF-R2 kinase inhibitory activity. Structure–activity relationships were investigated and compound 14a was shown to be efficacious in a mouse model of corneal neovascularization.
Graphical abstractA novel series of 4-aryl-5-cyano-2-aminopyrimidines 2 were synthesized and found to have potent VEGF-R2 kinase inhibitory activity. Structure–activity relationships were investigated and compound 14a was shown to be efficacious in a mouse model of corneal neovascularization.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Terry V. Hughes, Stuart L. Emanuel, Amanda K. Beck, Steven K. Wetter, Peter J. Connolly, Prabha Karnachi, Michael Reuman, Jabed Seraj, Angel R. Fuentes-Pesquera, Robert H. Gruninger, Steven A. Middleton, Ronghui Lin, Jeremy M. Davis, David F.C. Moffat,