| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377581 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
VirA–VirG two-component system regulates the vir (virulence) operon in response to specific host factors (xenognosins) in the plant pathogen Agrobacterium tumefaciens. Using whole cell assays, stable inhibitors inspired by the labile natural benzoxazinone inhibitor HDMBOA are developed. It is found that aromatic aldehydes represent a minimal structural unit for activity. In particular, 3-hydroxy-4,6-dimethoxy-3H-isobenzofuran-1-one (HDI) was found to have the highest activity, making it the most potent developed inhibitor of virulence gene expression in Agrobacterium.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Justin Maresh, Jin Zhang, Yih-Ling Tzeng, Nora A. Goodman, David G. Lynn,