Synthesis and cytotoxic activity of trisubstituted-1,3,5-triazines

1,3,5-Triazine derivatives were screened for phototoxicity as well as the cytotoxic activities against leukemia and adenocarcinoma derived cell lines in comparison to the normal human keratinocytes. A simple and environmentally friendly procedure has been developed for the synthesis of 1,3,5-triazine derivatives under microwave irradiation in the presence of a HY zeolite. The catalyst can be recovered and reused. Thus, the procedure provides a simple and green synthetic methodology under environmentally friendly conditions. Structure–activity relationships between the chemical structures and antimycobacterial and photosynthesis-inhibiting activity of the evaluated compounds are also discussed.

Graphical abstractA simple and environmentally friendly procedure has been developed for the synthesis of 2,4,6-trisubstituted-1,3,5-triazines using HY zeolite under microwaves and synthesized compounds screened for cytotoxic, antimicrobial, and photosynthesis-inhibiting activities.Figure optionsDownload full-size imageDownload as PowerPoint slide