Article ID Journal Published Year Pages File Type
1377588 Bioorganic & Medicinal Chemistry Letters 2007 5 Pages PDF
Abstract

Series of ureas and thioureas were designed and synthesized, and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. We found several essential moieties in the structure of the prepared compounds for the activity. Thiourea derivatives revealed higher inhibitory activity than the corresponding urea derivatives. Among these compounds, 7e having carboxymethyl group at N3 position of thiourea was the most potent in the inhibition of NO production. They inhibited NO production through the suppression of iNOS protein and mRNA expression.

Graphical abstractSynthesis of series of ureas and thioureas and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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