Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377590 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of novel acylide derivatives have been synthesized from erythromycin A via a facile procedure. By applying this procedure, cyclic carbonation to C-11,12 position, acylation to C-3 hydroxyl, and deprotection provided the desired acylides. These compounds showed antibacterial activity against both macrolide-susceptible strains and macrolide-resistant strains. Because of existence of 6-O-allyl substitution, these derivatives can be used as intermediates for further structural modification.
Graphical abstractA facile way to assemble a series of potent acylide derivatives against both macrolide-susceptible and macrolide-resistant strains was reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Peng Xu, Lu Liu, Zhiping Jin, Pingsheng Lei,