Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377591 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A series of benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides were synthesized and their binding to two carbonic anhydrase isozymes measured by isothermal titration calorimetry (ITC). Human carbonic anhydrase I (hCAI) and bovine carbonic anhydrase II (bCAII) bound the inhibitors with observed association constants in the range from 1.1 × 106 to 2.6 × 107 M−1.
Graphical abstractSynthesis and binding of the novel carbonic anhydrase inhibitors are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Virginija Dudutienė, Lina Baranauskienė, Daumantas Matulis,