Article ID Journal Published Year Pages File Type
1377594 Bioorganic & Medicinal Chemistry Letters 2007 5 Pages PDF
Abstract

A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.

Graphical abstractA potent series of broad-spectrum antivirals against human herpesviruses has been identified which inhibit HCMV, HSV-1, EBV, and VZV polymerases.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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