Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377594 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.
Graphical abstractA potent series of broad-spectrum antivirals against human herpesviruses has been identified which inhibit HCMV, HSV-1, EBV, and VZV polymerases.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mark E. Schnute, David J. Anderson, Roger J. Brideau, Fred L. Ciske, Sarah A. Collier, Michele M. Cudahy, MariJean Eggen, Michael J. Genin, Todd A. Hopkins, Thomas M. Judge, Euibong J. Kim, Mary L. Knechtel, Sajiv K. Nair, James A. Nieman,