Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377596 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
High-throughput screening hit 1 was identified as a potent, broad-spectrum, non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 replication. Analysis of the bound conformation of analogs of this inhibitor via molecular modeling and NMR contributed to the design of novel tertiary amide, carbamate, and thiocarbamate based NNRTIs.
Graphical abstractTetrazole thioacetanilides such as 12 were identified as potent NNRTIs via high-throughput screening. Analysis of the binding mode of these inhibitors permitted the successful scaffold hop to tertiary amides (23), carbamates (24), and thiocarbamates (26).Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jeff A. O’Meara, Araz Jakalian, Steven LaPlante, Pierre R. Bonneau, René Coulombe, Anne-Marie Faucher, Ingrid Guse, Serge Landry, Jennifer Racine, Bruno Simoneau, Bounkham Thavonekham, Christiane Yoakim,