| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377598 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of β-aminoamides bearing triazolopiperazines has been prepared and evaluated as potent, selective, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. Efforts at optimization of the β-aminoamide series, which ultimately led to the discovery of JANUVIA™ (sitagliptin phosphate, compound 1), are described.
Graphical abstractA series of β-aminoamides bearing triazolopiperazines has been prepared and evaluated as potent, selective, orally active dipeptidyl peptidase IV (DPP-4) inhibitors.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Dooseop Kim, Jennifer E. Kowalchick, Scott D. Edmondson, Anthony Mastracchio, Jinyou Xu, George J. Eiermann, Barbara Leiting, Joseph K. Wu, KellyAnn D. Pryor, Reshma A. Patel, Huaibing He, Kathryn A. Lyons, Nancy A. Thornberry, Ann E. Weber,