| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377599 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D.
Graphical abstractThe design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Steven W. Kortum, Timothy E. Benson, Michael J. Bienkowski, Thomas L. Emmons, D. Bryan Prince, Donna J. Paddock, Alfredo G. Tomasselli, Joseph B. Moon, Alice LaBorde, Ruth E. TenBrink,