Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377601 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A series of novel stearoyl-CoA desaturase 1 (SCD1) inhibitors were identified by scaffold design based on known SCD1 inhibitors. Large structural changes were made leading to multiple analogs with comparable or improved potency. This approach is valuable for generation of proprietary compounds without conducting a costly high-throughput screening.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hongyu Zhao, Michael D. Serby, Harriet T. Smith, Ning Cao, Tom S. Suhar, Teresa K. Surowy, Heidi S. Camp, Christine A. Collins, Hing L. Sham, Gang Liu,