| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377606 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of substituted bis[(para-methoxy)benzyl] (bisPMB) esters of 1-naphthalenemethylphosphonate (NMPA) were synthesized and evaluated as phosphonate prodrugs. BisPMB NMPA esters (4b and 4c) with significantly improved aqueous stability were identified that also resulted in increased intracellular levels of NMPA following prodrug incubation with primary rat hepatocytes.
Graphical abstractA series of bis[(para-methoxy)benzyl] phosphonate esters were synthesized and evaluated as phosphonate prodrugs. Two esters (4b and 4c) were identified with significantly improved aqueous stability and enhanced penetration to primary rat hepatocytes.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Qun Dang, Yan Liu, Robert M. Rydzewski, Brian S. Brown, Edward Robinson, Paul D. van Poelje, Timothy J. Colby, Mark D. Erion,