Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377608 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of piperidine amide inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) were identified via modifications of the HTS hit compound 1. The synthesis, in vitro biological evaluation, and structure–activity relationship of these compounds are presented.
Graphical abstractCompound 1 was identified as a potent 11β-HSD1 inhibitor in a HTS screen. Synthesis and inhibitory potency of analogs to 1 are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Katarina Flyrén, Lars O. Bergquist, Victor M. Castro, Christopher Fotsch, Lars Johansson, David J. St. Jean Jr., Lori Sutin, Meredith Williams,