| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377611 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones was designed, synthesized, and evaluated as human chymase inhibitors. From this series, we identified several compounds which were effective, via oral administration, in a mouse model of chronic dermatitis.
Graphical abstractA novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones was designed, synthesized, and evaluated as human chymase inhibitors. From this series, we identified several compounds which were effective, via oral administration, in a mouse model of chronic dermatitis.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hiroshi Maruoka, Tsuyoshi Muto, Taisaku Tanaka, Seiichi Imajo, Yoshiaki Tomimori, Yoshiaki Fukuda, Takashi Nakatsuka,