Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377612 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
The technetium-99m-labeling and synthesis of a series of thymidine analogs were studied. The target molecules were obtained by using 6-hydrazinopyridine-3-carboxylic acid (HYNIC) as a bifunctional coupling agent and using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) and ethylenediamine-N,N′-diacetic acid (EDDA) as coligands. The effects of different spacers between thymidine analog with HYNIC on radiochemical yield were also studied.
Graphical abstractThe synthesis and labeling of a series of thymidine analogs were reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bao Teng, Yunpeng Bai, Yu Chang, Shizhen Chen, Zhaolong Li,