| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377661 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
The synthesis and biological evaluation of a novel family of M3 muscarinic antagonists are described. A systematic modification of the substituents to a novel alkyne-quinuclidine scaffold yielded original compounds displaying potent in vitro anticholinergic properties.
Graphical abstractThe synthesis and biological evaluation of a novel family of M3 muscarinic antagonists are described. A systematic modification of the substituents to a novel alkyne-quinuclidine scaffold yielded original compounds displaying potent in vitro anticholinergic properties.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Jean-Philippe Starck, Patrice Talaga, Luc Quéré, Philippe Collart, Bernard Christophe, Patrick Lo Brutto, Sophie Jadot, Dinesh Chimmanamada, Matteo Zanda, Alain Wagner, Charles Mioskowski, Roy Massingham, Michel Guyaux,