| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377666 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
We report the discovery of novel histamine H3 receptor antagonists based on 4-[(1H-imidazol-4-yl)methyl]piperidine. The most potent compounds in the series (e.g., 7) result from the attachment of a substituted aniline amide to the main pharmacophore piperidine via a two-methylene linker.
Graphical abstractWe report the discovery of novel histamine H3 receptor antagonists based on 4-[(1H-imidazol-4-yl)methyl]piperidine. The most potent compounds in the series (e.g., 7) result from the attachment of a substituted aniline amide to the main pharmacophore piperidine via a two-methylene linkerFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Wayne D. Vaccaro, Rosy Sher, Michael Berlin, Neng-Yang Shih, Robert Aslanian, John H. Schwerdt, Kevin D. McCormick, John J. Piwinski, Robert E. West Jr., John C. Anthes, Shirley M. Williams, Ren-Long Wu, H. Susan She, Maria A. Rivelli,