Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377692 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
A new series of 1,2,4-triazoles was synthesized and tested against several NNRTI-resistant HIV-1 isolates. Several of these compounds exhibited potent antiviral activities against efavirenz- and nevirapine-resistant viruses, containing K103N and/or Y181C mutations or Y188L mutation. Triazoles were first synthesized from commercially available substituted phenylthiosemicarbazides, then from isothiocyanates, and later by condensing the desired substituted anilines with thiosemicarbazones.
Graphical abstractA new series of 1,2,4-triazoles was synthesized and tested against several NNRTI-resistant HIV-1 isolates containing K103N and/or Y181C mutations or Y188L mutation.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Martha De La Rosa, Hong Woo Kim, Esmir Gunic, Cheryl Jenket, Uyen Boyle, Yung-hyo Koh, Ilia Korboukh, Matthew Allan, Weijian Zhang, Huanming Chen, Wen Xu, Shahul Nilar, Nanhua Yao, Robert Hamatake, Stanley A. Lang, Zhi Hong, Zhijun Zhang,