| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377693 | Bioorganic & Medicinal Chemistry Letters | 2006 | 8 Pages |
Abstract
The design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited potent binding affinity and functional activity at MCH-R1, and good oral bioavailability in rat.
Graphical abstractThe design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited potent binding affinity and functional activity at MCH-R1, and good oral bioavailability in rat.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Martin W. Rowbottom, Troy D. Vickers, Brian Dyck, Jonathan Grey, Junko Tamiya, Mingzhu Zhang, Mehrak Kiankarimi, Dongpei Wu, Wesley Dwight, Warren S. Wade, David Schwarz, Christopher E. Heise, Ajay Madan, Andrew Fisher, Robert Petroski,