| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377697 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A metabolism study of FK788 (2) led to the discovery of new diphenylcarbamoyl derivatives as prostacyclin mimetics without the PG skeleton. We designed and evaluated PGI2 mimetics based on blocking the main metabolic pathway of FK788. The new compound 7c was found to be equipotent to FK788 towards PGI2 agonist activity and metabolically more stable than FK788.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fujiko Takamura, Akira Tanaka, Hisashi Takasugi, Kiyoshi Taniguchi, Mie Nishio, Jiro Seki, Kouji Hattori,